Oxygen saturation in adolescent high-altitude residents, implications for clinical decision-making
DOI:
https://doi.org/10.35319/conr.20268147Keywords:
Oxygen saturation, pulse oximetry, adolescent, environmental hypoxia, altitude, reference valuesAbstract
In high-altitude cities such as El Alto (4150 meters above sea level), reference values established at sea level are still applied, which can lead to misdiagnosis, overestimation of respiratory pathologies and clinical decisions with direct repercussions on nursing care. A quantitative, descriptive and cross-sectional study was carried out in 94 adolescents living permanently in El Alto, selected under inclusion and exclusion criteria (absence of acute respiratory infection, anemia, lung disease, pregnancy and tobacco use). Oxygen saturation was measured by non-invasive digital pulse oximetry, after three minutes of rest and with three consecutive readings, registering the most stable value. 71 % were 14 years old; 60 % male, 40 % female. The saturations at rest were; 47 % between 91-95 %, 42 % between 86-90 %, 7% between 80-85 % and 2 % between 96-100 %. The average was 88.2 % in 14-year-olds, 91.3 % in 15-year-olds, and 95% in 16-17-year-olds. The heart rate was between 91-100 bpm in 21 % of cases, and only 2 % reported a respiratory history. Most of them had saturations between 88 and 95 %, values compatible with a physiological adaptation to chronic hypobaric hypoxia typical of extreme altitude. These evaluations show the need to have contextualized reference values for populations living at high altitudes, avoiding inappropriate clinical interpretations and optimizing care decision-making.
Downloads
References
Guyton AC, Hall JE. Transporte de oxígeno y dióxido de carbono en la sangre y los líquidos corporales. En: Tratado de Fisiología Médica. 13.ª ed. Madrid: Elsevier; 2017. p. 503-20.
Hall JE. Regulación de la respiración y transporte de oxígeno. En: Guyton y Hall. Fisiología Médica. 14.ª ed. Barcelona: Elsevier; 2021. p. 529-45.
Wukitsch MW, Petterson MT, Tobler DR, Pologe JA. Pulse oximetry: analysis of theory, technolo-gy, and practice. J Clin Monit 1988;4(4):290-301. DOI: https://doi.org/10.1007/BF01617328
Severinghaus JW, Naifeh KH. Accuracy of response of six pulse oximeters to profound hypoxia. Anesthesiology 1987;67(4):551-8. DOI: https://doi.org/10.1097/00000542-198710000-00017
Ralston AC, Webb RK, Runciman WB. Potential errors in pulse oximetry. I. Pulse oximeter evalua-tion. Anaesthesia 1991;46(3):202-6. DOI: https:// doi.org/10.1111/j.1365-2044.1991.tb09410.x
Jubran A. Pulse oximetry. Intensive Care Med 2004;30:2017-20. DOI: https://doi.org/10.1007/s00134-004-2399-x
Subhi R, Smith K, Duke T. When should oxygen be given to children at high altitude? A systematic review to define altitude-specific hypoxaemia. Arch Dis Child 2009;94(1):6-10. DOI: https://doi.org/10.1136/adc.2008.138362
West JB. Oxygen transport at high altitude. In: High Altitude Medicine and Physiology. 5th ed. Boca Raton: CRC Press; 2013. p. 25-52.
Gamponia MJ, Babaali H, Yugar F, Gilman RH. Reference values for pulse oximetry at high altitude. Arch Dis Child 1998;78(5):461-5. DOI: https://doi.org/10.1136/adc.78.5.461
McCollum ED, King C, Deula R, Zadutsa B, Mankhambo L, Nambiar B, et al. Pulse oximetry for children with pneumonia treated as outpatients in rural Malawi. Bull World Health Organ 2016; 94(12):893-902. DOI: https://doi.org/10.2471/BLT.16.173401. Erratum in: Bull World Health Organ. 2017;95(1):81. DOI: https://doi.org/10.2471/BLT.17.100117
Vargas E, Spielvogel H. Chronic mountain sickness, optimal hemoglobin, and heart disease. High Alt Med Biol. 2006;7(2):138-49. DOI: https://doi.org/10.1089/ham.2006.7.138
Grimm M, Seglias A, Ziegler L, Mademilov M, Isaeva E, Tynybekov K, et al. Sleep apnea in school-age children living at high altitude. Pulmonology 2023;29(5):385-91. DOI: https://doi.org/10.1016/j.pulmoe.2023.02.008
Beall CM. Adaptation to high altitude: Phenotypes and genotypes. Annu Rev Anthropol 2014;43: 251-72. DOI: https://doi.org/10.1146/annurev-anthro-102313-030000
Arias-Stella J, Recavarren S. The pulmonary circulation at high altitudes. Circulation. 1962;26: 915-22. DOI: https://doi.org/10.1161/01.CIR.26.6.915
Mortola JP. Children’s breathing at high altitude. Respir Physiol Neurobiol. 2007;158(2-3):123-30. DOI: https://doi.org/10.1016/j.resp.2007.04.009
Andrade V, Andrade F, Riofrio P, Nedel FB, Martin M, Romero-Sandoval N. Pulse oximetry curves in healthy children living at moderate altitude: a cross-sectional study from the Ecuado-rian Andes. BMC Pediatr 2020;20(1):440. DOI: https://doi.org/10.1186/s12887-020-02334-z
Ucrós S, Granados CM, Castro-Rodríguez JA, Hill CM. Oxygen saturation in childhood at high altitude: a systematic review. High Alt Med Biol 2020;21(2):114-25. DOI: https://doi.org/10.1089/ham.2019.0077
Tüshaus L, Moreo M, Zhang J, Hartinger SM, Mäusezahl D, Karlen W. Physiologically driven, altitude-adaptive model for the interpretation of pediatric oxygen saturation at altitudes above 2,000 m a.s.l. J Appl Physiol 2019;127(3):847-57. DOI: https://doi.org/10.1152/japplphysiol.00478.2018
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2026 Current Opinion Nursing & Research

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
